Curriculum Vitae

James Kwan

RESEARCH

2016 - Current: Principal Investigator: Nanyang Technological University – Singapore, 637459, SG

2015 - 2016 | Chemical Engineer | OxSonics Ltd. – Oxford, OX4 4GA, UK

2012 - 2015 | Postdoc | University of Oxford – Oxford, OX4 1HU, UK

2011 -2012 | Postdoc | University of Colorado, Boulder – Boulder, CO, 80303, USA

2007 - 2011 | PhD | Columbia University – New York, NY, 10027, USA

2003 - 2007 | Undergraduate Researcher | Rensselaer Polytechnic Institute – Troy, NY, 12180, USA

EDUCATION

2012 | Ph.D – Chemical Engineering | Columbia University – New York, NY, 10027

Thesis: Phospholipid Encapsulation Properties and Effects on Microbubble Stability and Dynamics

2011 | MPhil – Chemical Engineering | Columbia University – New York, NY, 10027

2009 | M.S. – Chemical Engineering | Columbia University – New York, NY, 10027

2007 | B.S. – Chemical Engineering | Rensselaer Polytechnic Institute – Troy, NY, 12180

FELLOWSHIPS

2013 - 2015 | W.W. Spooner Junior Research Fellowship | New College – University of Oxford

GRANTS

2016 | NTU-ICES Joint Science Workshop | 20,000.00 SGD | "Acoustically induced gelation from ultrasound-responsive materials"

2016 | NTU Internal Grant | 300,000.00 SGD | "Ultrasound-responsive materials and nano/micro-devices for therapeutic and diagnostic applications"

2013 | W.W. Spooner Junior Research Fellowship at New College, University of Oxford | 51,000 GBP (estimated*)

*In kind supporting research funds and social amenities

 PATENTS

Cavitation Inducing Polymeric Nanoparticles (PCT/GB2014/053416)

Isolation of Microbubbles of Selected Size Range from Polydisperse Microbubbles (US2011/0300078 A1)

 PUBLICATIONS

(H-Index: 10) [Impact Factor; Citations as of 02/17 – Google Scholar]

Peer Reviewed Journal Articles: [Total citations – 603]

J.J. Kwan; G. Lajoinie; E. Stride; M. Versluis; C.C. Coussios, “Ultra-high Speed Imaging of Cavitation Dynamics from Nanocups”, Physical Review Applied, 2016: 6 (4), 044004 [4.061]

S. Bhatnagar; J.J. Kwan; S.A. Yeh; A. Shah; R. Carlisle; C.C. Coussios, “Acoustic cavitation-enhancing polymeric nanoparticles for transdermal vaccination and the generation of vaccine-specific antibodies in mice”, Journal of Controlled Release, 238, 22-30 [7.705]

R. Myers; C.M. Coviello; P. Erbs; C. Rowe; J.J. Kwan; C. Crake; S. Finn; E. Jackson; J.M. Balloul; C. Story; C.C. Coussios; R. Carlisle, “Polymeric Cups for Cavitation Mediated Delivery of Oncolytic Vaccinia Virus”, Molecular Therapy, 24, 9, 1627-1633 [6.251]

J.J. Kwan; R. Myers; C.M. Coviello; S.M. Graham; A. Shah; R. Carlisle; E. Stride; C.C. Coussios, “Ultrasound-propelled Nanocups for Drug Delivery”, Small, 2015 [8.368]

J.J. Kwan; S.M. Graham; R. Myers; R. Carlisle; E. Stride; C.C. Coussios, “Ultrasound-induced Inertial Cavitation from Gas-stabilizing Nanoparticles”, Physical Review E, 2015 [2.313]

J.J. Kwan and M.A. Borden, “Lipid Monolayer Collapse and Microbubble Stability”, Advances in Colloid and Interface Science, 2012: 183-4; pp 82 – 99 [8.372]

J.J. Kwan; M. Kaya; M.A. Borden; P.A. Dayton, “Theranostic Oxygen Delivery Using Ultrasound and Microbubbles”, Theranostics, 2012 [8.022]

J.J. Kwan and M.A. Borden, “Lipid Monolayer Dilatational Mechanics during Microbubble Gas Exchange”, Soft Matter, 2012: 8; pp. 4756 – 66 [4.39]

L. Mullin; R. Gessner; J.J. Kwan; M. Kaya; M.A. Borden; P.A. Dayton, “Effect of Anesthesia Carrier Gas on In Vivo Circulation Times of Ultrasound Microbubble Contrast Agents in Rats”, Contrast Media and Molecular Imaging, 2011: 6; pp. 126 – 31 [3.328]

S. Sirsi; J. Feshitan; J.J. Kwan; M.A. Borden, “Effect of Microbubble Size on Fundamental Mode High Frequency Ultrasound Imaging in Mice”, Ultrasound in Medicine and Biology, 2010: 36; 935 – 48 [2.493]

J.J. Kwan and M.A. Borden, “Microbubble Dissolution in a Multigas Environment”, Langmuir, 2010: 26; pp. 6542 – 48 [4.186]

J. Feshitan; C.C. Chen; J.J. Kwan; M.A. Borden, “Microbubble Size Isolation by Differential Centrifugation”, Journal of Colloid and Interface Sciences, 2009: 329; pp. 316 – 24 [3.263]

Peer Reviewed Book Chapters:

M.A. Borden; S. Sirsi; J.J. Kwan, “Microbubble Stability and Dynamics”, Encyclopedia of Surface and Colloid Science, 2012 (doi: 10.1081/e-escs-120047323)

J.J. Kwan and C.C. Coussios, “Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles”, Design and Applications of Nanoparticles in Biomedical Engineering

CONFERENCE ABSTRACTS & PRESENTATIONS

Invited Talks (presenter in bold):

J.J. Kwan, R. Myers, S. Graham, A. Shah, C. Coviello, D. Carugo, R. Carlisle, E. Stride, C. Coussios (2015), “Ultrasound-Induced Inertial Cavitation from Nanoparticles for Cancer Therapy”, University of Western Australia, Perth, Australia

J.J. Kwan, R. Myers, S. Graham, A. Shah, C. Coviello, R. Carlisle, E. Stride, C. Coussios (2014), “Ultrasound-Induced Inertial Cavitation from Nanoparticles for Cancer Therapy”, Superhydrophobicity, Bubble Stability, and Heterogeneous Nucleation, Rome, Italy

J.J. Kwan, R. Myers, S. Graham, A. Shah, C. Coviello, R. Carlisle, E. Stride, C. Coussios (2014), “Nanoparticle Induced Inertial Cavitation for Enhanced Drug Delivery to Tumours”, University of Twente, Enschede, The Netherlands

Selected Oral Conference Proceedings (presenter in bold): (5 out of 15 shown)

J.J. Kwan, G. LaJoinie, E. Stride, M. Versluis, C. Coussios (2015), “Bubble dynamics of inertial cavitation from nanoparticles”, International Society for Therapeutic Ultrasound, Utrecht, NL

R. Myers, S. Graham, J.J. Kwan, A. Shah, S. Mo, R. Carlisle, C. Coussios (2014), “Evaluation of Sub-micron, Ultrasound-responsive Particles as a Drug Delivery Strategy”, Acoustical Society of America, Providence, RI

J.J. Kwan, S. Graham, R. Myers, A. Shah, L. Seymour, R. Carlisle, E. Stride, C. Coussios (2014), “Inertial Cavitation at the Nanoscale”, International Society for Therapeutic Ultrasound, Las Vegas, NV

J.J. Kwan and M.A. Borden, (2011), “Phospholipid Encapsulation Properties and Effects on Microbubble Stability and Dynamics”, American Institute for Chemical Engineers - Annual Meeting, Minneapolis, MN

J.J. Kwan and M.A. Borden, (2010), “Microbubble Dissolution in a Multigas Environment”, American Institute for Chemical Engineers - Annual Meeting, Salt Lake City, UT

Selected Poster Conference Proceedings (presenter in bold): (2 out of 3 shown)

J.J. Kwan and M.A. Borden, (2009), “Lipid Coated Microbubble Multi-Gas Dissolution”, American Institute for Chemical Engineers - Annual Meeting, Nashville, TN

J. Feshitan, J.J. Kwan, and M.A. Borden, (2008), “Kinetically Controlled Design of Microbubbles for Targeted Delivery and Molecular Imaging”, Gordon Research Conference - Drug Carriers in Medicine & Biology, Big Sky, MT

 AWARDS AND HONORS

W.W. Spooner Junior Research Fellowship

Dean’s List At Rensselaer Polytechnic Institute (2003 – 2007)

Leadership Scholarship (2003 – 2007)

National Honour Society (2002 – 2003)

PROFESSIONAL SOCIETY MEMBERSHIP

American Institute for Chemical Engineers (2004 – 2012, 2015 - Current)

Biomedical Engineering Society (2015 - Current)

Oxford and Cambridge Club (2016 -  Current)

TEACHING ACTIVITIES

Columbia University – New York, NY, 10027

·   Chemical Engineering Control (CHEN E4300)

·   Transport Phenomenon II (CHEN E3120)

·   Principles of Chemical Engineering Thermodynamics (CHEN E3010

Mentoring Activities:

Doctoral Candidates:

2016 Deepika Lakshmi

2016 Xiaoqian Su

2012 Susan Graham

2012 Rachel Myers

2012 Sunali Bhatnagar

Master Students:

2014 Amalia Hadjitheodorou

Undergraduate Students:

2017 Sophie Hall

2011 Carly Anna Barnard

2011 Jocelyn Mulkey

2009 Richard Li

High School Students:

2008 Andrew Pesco

JOURNAL REFEREE

Royal Academy of Chemistry

Materials

Ultrasound in Medicine and Biology

Annuls of Biomedical Engineering

Langmuir

Journal of Industrial & Engineering Chemistry

Chemical Engineering Research and Design

EXTRACURRICULAR ACTIVITIES

·   New College Adviser to International Human Rights Law students (July 2015)

·   New College Adviser to International Human Rights Law students (August 2014)

·   Biocolloids Lab Tour Guide for Girls Explore Engineering (November 2011)

·   Treasurer of Graduate Student Association at Columbia University (2008 – 2010)

·   Acting Secretary for ΩΧΕ, a Chemistry Honor Society (2006 – 2007)

·   Head of Judging Committee for the AIChE Regional Conference in April ’06 (2006)

·   President of Rensselaer’s Community Action Volunteer Engagement (2004 – 2005)